The article reviews China’s extensive journey in microecology research, highlighting its impact on the global One Health framework, which emphasizes the interconnectedness of human, animal, and environmental health. Originating in the 1950s, Chinese scientists pioneered the idea that disruptions in microbial communities could lead to illness. Advancements in DNA sequencing have since enabled a deeper understanding of microbial interactions.
Today, research spans human health, agriculture, and environmental restoration, presenting promising applications. However, challenges remain, including establishing causal relationships and inconsistent data standards. The authors advocate for interdisciplinary collaboration and data sharing to translate research into practical solutions, aiming to enhance health, food security, and ecological resilience in the face of modern challenges.