Popular Gym Supplement Could Help With Depression
We already know exercise can boost mental health—but what if something from the gym aisle could do the same?
Creatine, one of the world’s most popular fitness supplements, is best known for helping build muscle and improve strength. However, scientists are exploring a surprising possibility: it could also help with depression.
The mental health condition characterized by persistent low mood, feelings of hopelessness, and a loss of interest in activities is on the rise in the U.S. According to Gallup data, more than 18 percent of adults—around 47.8 million people—suffer from depression.
Nicholas Fabiano, a psychiatry resident at the University of Ottawa, mentioned to Newsweek, “Creatine is still very much in its early stages to determine efficacy with the largest amount of data in depression.”
Current Research Findings
Researchers, led by Bassam Jeryous Fares of the University of Ottawa, analyzed five existing clinical trials involving individuals with depression, and the results were mixed. For now, experts advise caution regarding recommending creatine for depression.
Two studies involving women with major depressive disorder reported promising benefits. In one study, participants who took five grams of creatine alongside the antidepressant escitalopram experienced more substantial improvements in their symptoms after eight weeks compared to those taking the drug alone. A greater number also reached remission. Conversely, three of the trials indicated no benefits, including in individuals with treatment-resistant depression, adolescent girls, and those with bipolar disorder.
Genetics and Individual Responses
Sarah Carolides, a functional medicine and nutrition expert, highlighted the role of genetics. She stated, “For the right person, creatine monohydrate could be a very useful addition to a protocol for depression—but it is not a one-size-fits-all remedy.”
Fares pointed out that there is not enough evidence to alter clinical practices since “two trials pointed one way and three pointed another.” Additionally, safety concerns emerged with two participants with bipolar disorder developing hypomania or mania while using the supplement.
Why Creatine Could Influence Mental Health
Creatine plays a key role in how energy is produced in the body. While it’s known for fuelling muscles, the brain relies on the same energy systems. Some scientists believe that disruptions in brain energy use may be partly linked to depression, suggesting that boosting energy supply could support mood. There’s also some evidence indicating that creatine may influence neurotransmitters like dopamine and serotonin, which are crucial for mood regulation. However, these links are still theoretical and not fully understood.
In summary, while the findings are intriguing, they aren’t yet strong enough to shift treatment approaches for depression. Creatine remains a well-known supplement posing questions about its potential mental health applications.
