Researchers in Spain studied the effects of three days of supplementation with methylcobalamin (branded as MecobalActive) on anaerobic performance and cognitive function in amateur cyclists. They posited that this supplementation could enhance physical and mental performance markers.
The study, published in Nutraceuticals, indicated that short-term methylcobalamin supplementation might influence performance and cognitive measures during high-intensity exercise for recreationally trained individuals.
Methylcobalamin vs Other Forms of Vitamin B12
Vitamin B12 is crucial for DNA synthesis, red blood cell formation, and neuromuscular function. Low B12 levels can lead to reduced oxygen transport, increased fatigue, slower recovery, and impaired athletic performance. It has several forms: cyanocobalamin, hydroxocobalamin, methylcobalamin (MeB12), and adenosylcobalamin. Methylcobalamin plays a key role in the methylation cycle, which is vital for DNA and protein regulation, and may impact mood and cognitive resilience.
While there is limited research on the effects of B12 supplementation on sports performance—often focusing more on hydroxocobalamin—the researchers found that methylcobalamin may offer superior tissue absorption and lower urinary loss.
Findings on Cycling Performance
The study featured 18 male amateur cyclists in a randomized, triple-blind, placebo-controlled crossover design, with participants receiving either MeB12 or a placebo. They undertook the study without other supplements or medications affecting vitamin B12 metabolism and went through three testing sessions, with a focus on cognitive and physical assessments post-exercise.
Results demonstrated that three days of MeB12 supplementation improved both physical and cognitive performance. Participants showed increased peak power output and less fatigue during high-intensity cycling sprints. Cognitive performance also enhanced, with quicker reaction times noted.
The authors theorized that these performance gains could stem from improved neuromuscular function and central nervous system effects. They suggested that MeB12 could lower perceived exertion and boost motor output by enhancing nerve conduction and neuromuscular efficiency.
Additionally, the report noted potential antioxidant effects from vitamin B12, which may enhance the activity of antioxidant enzymes.
Conclusion and Future Research
In conclusion, the study highlighted the positive impact of methylcobalamin supplementation on athletic performance in amateur cyclists. The researchers indicated that further investigation is needed to explore other functional markers, like methylmalonic acid, to better assess the vitamin’s efficacy.
Source: Nutraceuticals; doi: 10.3390/nutraceuticals6020035.
