Researchers from Australia and Denmark evaluated the effects of a sugarcane-derived supplement called PRSE on cardiometabolic and microbiome markers in a 90-day crossover study. They found the supplement positively influenced lipid metabolism and microbial pathways, though it did not affect microbial diversity, body weight, or inflammatory markers.
PRSE, derived from sugarcane molasses, contains concentrated antioxidants and phytochemicals without sugar. Though the study showed modest changes in metabolic pathways among healthy participants, it highlights PRSE’s potential role in managing oxidative stress and inflammation linked to chronic diseases.
Study Details:
- A quadruple-blinded, randomized, placebo-controlled crossover trial included 56 healthy adults, with data from 47 participants.
- Participants took either 500 mg/day of PRSE or a placebo for 90 days before switching groups.
- Key outcomes included blood and fecal samples to measure cardiometabolic biomarkers and gut function, along with participant health questionnaires.
Key Findings:
- The placebo group saw increases in triglycerides and VLDL cholesterol, whereas those taking PRSE maintained stable levels and showed a slight decrease in trans-fatty acids.
- Significant differences in gut metabolic functional pathways were noted, but there were no changes in markers of microbial diversity or mood.
The researchers suggest caution in applying these findings to populations with obesity or metabolic disorders and recommend further studies to explore the broader implications.
Source: Frontiers in Nutrition; doi: 10.3389/fnut.2026.1923420.
